2016-2018 Funded Projects and Outcomes


Determination of mefloquine’s intrinsic clearance by feline microsome. Could this be a suitable treatment for Feline Infectious Peritonitis (FIP)?
Dr M Govendir, Dr J Norris, Dr A Izes

The overall aim is to investigate some in vitro pharmacokinetic indices of mefloquine specific to cats. Given that clinically normal cats have problems clearing some drugs, e.g. paracetamol and propofol, sick cats may have even greater difficulty with hepatic clearance. As such, the aim of this study is to use an in vitro model of feline hepatic metabolism to ascertain whether mefloquine is likely to accumulate in the cat. This information will be used to model a starting dosage and determine whether administration of mefloquine is likely to accumulate in live cats.

2017 Round 1

Duration of antibody response in feline immunodeficiency virus (FIV)-vaccinated cats and the resulting impact on FIV testing using point-of-care kits
Dr Westman, Professor J Norris, Dr R Malik

Question: Whether false-positive FIV results occur using point-of-care antibody cats in cats recently given an annual FIV booster vaccination. This question is important for all cats but especially in shelters performing FIV testing prior to adoption where incorrect FIV diagnosis may lead to unnecessary euthanasia, as well as to develop understanding of the immunological (antibody mediated) response that occurs following annual booster FIV vaccination. The same frequency of false-positive results may not occur with annual booster vaccination as with primary vaccination since a reduced or negligible antibody response is sometimes noted following re-vaccination compared to primary vaccination.

(This is the third grant for this work, each grant building on the previous grants, and the results were very useful. They have been presented internationally and impacted on practice.)

2017 Round 2

Investigating feline morbillivirus epidemiology in domestic cats in Perth, Western Australia
Dr C Sharp, Dr T Hyndman, Dr T O’Dea

2018 Round 1

Molecular surveillance for haemotropic parasites and bacterial pathogens in cats from Brisbane
Ms T Greay, Professor P Irwin

This project aims to investigate recently-discovered, tick-associated bacteria and parasites in cats in Brisbane, and will determine the prevalence of bacterial and parasitic infections in cats in selected suburbs.

2018 Round 2

Development of a rapid diagnostic method for feline infectious peritonitis
Dr Seyed Ghorasi, Dr Joanne Connolly, Dr Martin Combs, Dr Randi Rotne, Dr Alison Montgomery

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Helen Radoslovich: 0408 812 319