2016 Funded Projects and Outcomes


Determination of mefloquine’s intrinsic clearance by feline microsome. Could this be a suitable treatment for Feline Infectious Peritonitis (FIP)?
Dr M Govendir, Dr J Norris, Dr A Izes

The overall aim is to investigate some in vitro pharmacokinetic indices of mefloquine specific to cats. Given that clinically normal cats have problems clearing some drugs, e.g. paracetamol and propofol, sick cats may have even greater difficulty with hepatic clearance. As such, the aim of this study is to use an in vitro model of feline hepatic metabolism to ascertain whether mefloquine is likely to accumulate in the cat. This information will be used to model a starting dosage and determine whether administration of mefloquine is likely to accumulate in live cats.


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Helen Radoslovich: 0408 812 319